This paper describes a validated high-performance thin-layer chromatography (HPTLC) method for simultaneous estimation of Diclofenac Potassium (DKP) and Febuxostat (FEB) in tablet dosage form. An HPTLC method separation is achieved on an aluminum sheet of silica gel 60F254 using Chloroform: Methanol: Formic acid (14:0.4:0.2 v/v/v) as mobile phase. Quantification is achieved with UV detection at 293 nm over a concentration range of 100-500 ng/spot and 40-200 ng/spot with mean recovery of 99.16 ± 0.63 and 99.52 ± 0.71 for DKP and FEB, respectively, in the HPTLC method. Results showed that this method was simple, precise, and sensitive and it is applicable for the simultaneous determination of DKP and FEB in tablet dosage form.
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